Information for Patients
What is the PARROT Ireland study?
It is a research trial being conducted in the 7 largest Maternity hospitals of Ireland, involving pregnant women with suspected for pre-eclampsia, from June 2017 until December 2018. The trial will investigate if adding an extra blood test called Placental Growth Factor (PlGF) to routine care will help diagnose those women with pre-eclampsia faster, and weather this reduces complications to these women and their babies from pre-eclampsia.
What is pre-eclampsia?
Pre-eclampsia (PET) is a condition that affects about 5% of pregnant women. It can cause high blood pressure and protein in the urine and many organs in the body can be affected. It can result in severe complications to both mother and baby if the diagnosis is delayed. At present, we do not have an effective test to tell the difference between women with the symptoms of pre-eclampsia who are going to develop complications and those that will do well, and can be managed as an out-patient.
What is Placental Growth Factor (PlGF)?
Placental growth factor is a protein made by the placenta. Recent studies have examined whether checking a womans PlGF levels can help diagnose pre-eclampsia with very good results (PELICAN Study). By performing this trial we hope to show if adding a PlGF measurement test to routine clinical care will allow women with PET to be identified and treated earlier, thus reducing complications to them and their babies
Who can take part in the study?
If your doctor or midwife is concerned you may have signs or symptoms of pre-eclampsia and you are between 20-36+6 weeks pregnant you may be suitable to take part in the PARROT Ireland trial.
How will the study affect medical decision making?
Some women (control) will have the usual tests and routine care currently provided for their pregnancy. Other women (intervention) will have an extra blood test called PlGF performed in addition to routine care. This blood test will give extra information about how well their placenta is working and will let their doctor decide if they need extra care for the remainder of their pregnancy.
Who is organising, funding and sponsoring the study?
The study is being run organised and funded though the Health Research Board Mother & Baby Clinical Trials Network www.hrb-mbctni.ie and the INFANT centre www.infantcentre.ie It is sponsored by UCC. www.ucc.ie
The local hospital ethics committee at each participating maternity hospital has reviewed and approved the study protocol and patient information sheet.